Pigmented Villonodular Synovitis (PVNS)
Epidemiology:
Common sites:
Gross features:
- involves one or
more joints diffusely
- red-brown to
mottled orange-yellow
- joint synovium is tangled, folded, with finger-like
projections and nodules
- aggressive tumours may invade adjacent bone and soft tissues
Histologic features:
- often papillary
architecture
- polyhedral,
moderate-sized tumour cells resembling synoviocytes
- spreading along synovial surface and infiltrating the subsynovial compartment
- hemosiderin deposits
- foamy macrophages
- multinucleated
giant cells
- zones of sclerosis
Immunophenotype:
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Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- true neoplasm of synovial lining of joints
- similar to to Giant Cell Tumour of Tendon
Sheath (GCT)
- significant
recurrence rate
- often history of
trauma
References: