Clear Cell Carcinoma
Epidemiology:
Common sites:
Gross features:
Histologic features:
Immunophenotype:
Marker: |
Sensitivity: |
Specificity: |
CAIX |
very |
|
Brush-border
antigens |
|
|
LMWK (CK8, 18,
19, CAM5.2) |
|
|
Vimentin |
“many” |
|
CD10 |
Most (90%) |
|
AMACR (focal or
diffuse cytoplasmic) |
70% |
|
EMA |
Majority |
|
CD68 |
most |
|
MUC1 |
Most |
|
MUC3 |
Most |
|
PAS + / PASD –
(abundant glycogen) |
|
|
Hale’s
colloidal iron (absent or clumped/droplet-like) |
|
|
RCC marker |
most |
|
PLAP |
frequently |
|
CEA (neg) |
rarely |
|
Inhibin (neg) |
|
|
CK7 (neg) |
Focal
cytoplasmic in 25% |
|
CK20 (neg) |
|
|
HMWK (neg) |
Rarely
expressed |
|
S100 (neg) |
rarely |
|
AFP (neg) |
rarely |
|
CD117 (neg |
Focal
cytoplasmic in 7% |
|
Molecular features:
Other features:
References: