Multilocular Cystic Renal Cell Carcinoma

Epidemiology:

• Mean 51y
• M:F 3:1

Common sites:

Gross features:

• Multiple cysts containing serous or hemorrhagic fluid

Histologic features:

• clear cell morphology
• well-circumscribed
• fibrous capsule
• entirely composed of cysts
• small papillae may extend into cysts
• epithelium of simple cuboidal and clear cells
• septa:
• fibrous tissue
• aggregates of clear cells which do not form expansile nodules
• grade 1 nuclear characteristics

Immunophenotype:

Marker:	Sensitivity:	Specificity:
EMA
Cytokeratins
CD68 (neg)

Molecular features:

Other features:

• very good prognosis – no reported mets or recurrence

References: