Graft vs. Host Disease - Liver

Epidemiology and Etiology:

• Bone marrow transplantation

Common sites:

Gross features:

Histologic features:

• Acute (10-50d)
• Hepatitis
• Bile duct damage
• Cholestasis maybe
• Chronic (>100d)
• Portal tract inflammation
• Selective bile duct destruction
• Fibrosis eventually
• Endothelitis of portal and hepatic vein radicles maybe
• Cholestasis maybe

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

Other features:

References:

• Robbins Pathologic Basis of Disease (2005)