Adenomatous Hyperplasia
(Dysplastic Nodule)
Epidemiology and
Etiology:
- Cirrhosis
- Histologic spectrum between large
regenerative nodule and well-differentiated HCC
Common sites:
Gross features:
- Enlarged
cirrhotic nodule
- <1.5cm
usually
Histologic
features:
- Thick plates
- Moderate
increase in cell density
- Slightly
irregular trabecular pattern
- Variable
atypia
- Lack features
of definite malignancy
- Many portal
tracts within the nodule
- No
invasion into portal tracts (as in early HCC)
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- Precancerous
lesion to HCC
References:
- WHO
Pathology and Genetics of Tumours of the
Digestive System (2000)