Cholangiocarcinoma

Gross features:

• Tree-like mass or tumor nodule
• May have extensive intrahepatic metastases
• Firm and gritty (sclerotic)
• Rarely bile stained
• Metastases to lymph nodes in 50%
• Distant metastases often

Histologic features:

• Resemble adenocarcinomas, with a wide range of morphologic variation
• Most have clearly defined glandular and tubular structures lined by cuboidal to low columnar cells
• Dense, sclerotic stroma
• Vascular invasion may be prominent
• “Mixed variants” with areas of HCC, separated or co-mingled

Immunophenotype:

Marker:

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Molecular features:

Other features: