Cholangitis
Epidemiology:
Common sites:
Gross features:
Histologic features:
- abundant periductal, intramural, and intralumenal
neutrophils
- interlobular
ducts most affected, larger ducts may be normal
- abscess in portal
tract if duct ruptures
- neutrophils in sinusoids
- abscesses may form
in acini
- fibrin thrombi in
portal vein branches
- pylephlebitis
- parenchymal necrosis to various degrees
- cholestasis absent usually
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
References:
- Scheuer and Lefkowitch
2000