Cholestasis
Epidemiology:
Common sites:
Gross features:
Histologic features:
- portal tracts:
- Bile ductular proliferation (most consistent feature)
- Bile duct
distension
- Edema
- Bile pigment
retention
- Neutrophilic inflammation eventually
- Mild
- Restricted to cholestatic areas
- Fibrosis
eventually
- Hepatocyte changes in focal areas of cholestasis:
- enlargement of hepatocytes
- dilated canalicular spaces (bile plugs)
- apoptotic cells
present
- bile pigment
within hepatocytes
- fine, foamy reticular
cytoplasm (feathery degeneration)
- increase in
nuclear size and number
- a few mitoses
- Enlarged Kupffer cells with bile pigment
- Bile lakes
- Bile infarcts
sometimes:
- Substantial areas
of hepatocellular degeneration or death
- Pale or
bile-stained hepatocytes
- Discrete rounded
cells like macrophages
- Bile
- Fibrin often
abundant
- Liver-cell plates
remain mostly intact
Immunophenotype:
Marker:
|
Sensitivity:
|
Specificity:
|
PAS (Kupffer
cells)
|
|
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Molecular features:
Other features:
References: