Liver
Responses to Injury
Epidemiology:
Common sites:
Gross features:
Histologic features:
- toxic or
immunologic insult:
- hepatocyte swelling
- ballooning degeneration
when severe
- irregularly
clumped cytoplasmic organelles
- large clear
spaces
- lytic necrosis in extreme
- shards of
cellular debris
- cholestasis:
- hepatocyte swelling
- diffuse, foamy
appearance of cytoplasm (feathery degeneration)
- yellow discolouration of cytoplasm
- ischemic necrosis:
- centrilobular location
- poorly stained
- lysed nuclei
- apoptosis:
- round up
- shrunken
- intensely eosinophilic
- fragmented
nuclei
- interface
hepatitis
- regeneration:
- mitoses
- thickening of hepatocyte cords
- disorganization
of parenchymal structure
- ductular reaction:
- proliferation
of many serpentine ductules
Immunophenotype:
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Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
References: