Olfactory Neuroblastoma

(Esthesioneuroblastoma)

Epidemiology and Etiology:

Common sites:

• Superior and lateral nasal passage

Gross features:

Histologic features:

• Lobular nests encircled by vascularized connective tissue
• Small round cells
• Resemble neuroblasts

Immunophenotype:

Marker:	Sensitivity:	Specificity:
NSE
S-100
chromogranin

Molecular features:

Other features:

• Highly malignant
• Metastasize widely
• 5 year survival 50-70%
• EM – membrane-bound secretory granules (neuroendocrine feature)

References:

· Kumar V, Fausto N, Abbas A. Robbins & Cotran Pathologic Basis of Disease, Seventh Edition. 7th ed. Saunders; 2004.