Odontogenic Keratocyst (OKC)
Epidemiology:
Common sites:
Gross features:
Histologic features:
- cyst lining
consisting of thin layer of parakeratinized or orthokeratinized squamous
epithelium
- prominent basal
layer with basal cell pallisading
- corrugated
appearance of epithelial surface
- may see budding
of epithelium at the base, especially in Gorlin
syndrome
- epithelium often
separated from thin, uninflamed supporting
fibrous wall
Immunophenotype:
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Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- potentially aggressive,
requires adequate excision
- radiology:
- well-defined lucency
- unilocular or multilocular
- multiple lesions
may be seen in nevoid basal cell carcinoma syndrome (Gorlin syndrome)
References:
- Robbins 2005
- Mod Surg Path 2003