Oropharyngeal Squamous Cell Carcinoma

Common sites:

Gross features:

Histologic features:

• prognostic histologic features:
• pattern of invasion – noncohesive, irregular, jagged small cords and infiltrative, widespread single cells are worse than well-defined, blunt pushing borders or thick, rounded cords
• depth of invasion
• angiolymphatic invasion
• perineural invasion

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

• FGFR1 amplification (17% for >10% of cells with > 6 FGFR1 signals by FISH)

Other features: