Oropharyngeal Squamous Cell Carcinoma
Common sites:
Gross features:
Histologic features:
- prognostic histologic features:
- pattern of invasion – noncohesive, irregular,
jagged small cords and infiltrative, widespread single cells are worse
than well-defined, blunt pushing borders or thick, rounded cords
- depth of invasion
- angiolymphatic invasion
- perineural invasion
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
- FGFR1 amplification (17% for >10% of
cells with > 6 FGFR1 signals by FISH)
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Other features: