Brenner Tumour

Epidemiology:

• 2-3% of all ovarian neoplasms
• 30s to 70s

Common sites:

Gross features:

• solid or cystic
• borderline tumours tend to be cystic/multicystic with cauliflower-like masses protruding into one or more of the locules.
• 90% unilateral
• variable size (1 to 30cm)

Histologic features:

• sharply demarcated nests of transitional cells
• may have a central lumen with dense eosinophilic material or mucin
• often nests contain microcysts or glandular spaces lined by flat to columnar, mucin-secreting cells
• cells are polygonal to ovoid
• pale cytoplasm
• oval nuclei
• some nuclei have a central longitudinal groove
• fibrous stroma (adenofibroma)
• resembling normal ovarian stroma
• sometimes stroma is composed of somewhat plump fibroblasts resembling theca cells (may have hormonal activity)
• calcific plaques may be present
• borderline tumour:
• cysts with papillae protruding in the lumen
• lining cells are proliferating, mainly transitional type
• resemble papillary carcinoma of urinary tract
• mucin-containing cells may also be encountered at the surface
• no invasion of stroma
• malignant tumour (transitional cell carcinoma):
• nests of transitional carcinoma or occasionally squamous cell carcinoma
• irregular infiltrating pattern
• stromal invasion
• 3-tiered nuclear grading is recommended

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

Other features:

• occasionally associated with mucinous cystadenomas