Sertoli-Leydig cell tumour

Epidemiology and Etiology:

· 10s to 20s peak (all ages maybe)

Common sites:

·

Gross features:

· Unilateral

· Solid

· Gray to golden-brown

·

Histologic features:

· Tubules of Sertoli cells

· Leydig cells interspersed with stroma

· Eosinophilic cytoplasm

· Intracytoplasmic eosinophilic globules maybe

· Hyaline rod-like crystalloids of Reinke maybe

· Well-differentiated to poorly-differentiated

· Poorly-differentiated:

· Sarcomatous pattern

· Disorderly disposition of epithelial cell cords

· Heterologous elements maybe

· Mucinous glands

· Bone

· Cartilage

·

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

·

Other features:

· Masculinization or defeminization

· Or estrogenic effects

· <5% recurrence or metastasis

References:

· Kumar V, Fausto N, Abbas A. Robbins & Cotran Pathologic Basis of Disease, Seventh Edition. 7th ed. Saunders; 2004.