Serous Borderline Tumour
Epidemiology and Etiology:
- Progression to low-grade serous carcinoma
Common sites:
Gross features:
- increased amount of papillary projections in
cyst
- may occur on surface of ovary without cyst
formation
-
Histologic features:
- more complex papillae
- stratification of epithelium
- “budding”
- nuclear atypia
- scanty cytoplasm usually
- some cells may be bulbous with abundant eosinophilic
cytoplasm
- psammoma
bodies in 25%
- with microinvasion
(< 10 mm2 by definition):
- single cells or irregular nests or papillary
clusters present in the stroma
- not exceeding 3mm in maximum dimensions, or
10mm2 in area, in any one focus
- sometimes abundant eosinophilic cytoplasm
- peritoneal implants (definitions used only for
borderline tumours):
- epithelial non-invasive:
- papillary proliferations of atypical serous
cells
- on the surface of peritoneum with minimal
stromal component
- desmoplastic non-invasive:
- predominance of reactive stroma
- small glands and papillae lined with atypical
serous cells, as well as single cells and psammoma
bodies, entrapped in proliferating fibroblastic tissue
- often infiltrated with acute and chronic
inflammatory cells
- on the peritoneal surface
- necrosis, fibrin, hemorrhage occasionally
- invasive (actually these are histopathologically identical to LGSC, only
distinguished by timing and size of tumour,
where invasive implants are <= 1-2 cm):
- irregular infiltration and destruction of
underlying tissue
- clearing around islands of cells
- single eosinophilic cells
-
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
References: