Atypical Squamous Cells of Undetermined Significance (ASC-US)

 

Epidemiology:

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Common sites:

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Gross features:

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Cytologic features:

    • squamous differentiation
    • increased N:C ratio
      • nuclei ~2.5 to 3 times the area of a nucleus of a normal intermediate cell
    • minimal nuclear hyperchromasia, clumping, irregularity, smudging, or multinucleation
    • atypical parakeratosis
      • nuclear abnormalities associated with dense orangeophilic cytoplasm

 

Immunophenotype:

Marker:

Sensitivity:

Specificity:

 

 

 

 

Molecular features:

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Other features:

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