Normal /
Reactive Lymph Node
(ex. report)
Epidemiology:
Common sites:
Gross features:
Histologic features:
- Preservation
of lymph node architecture
- Polarization
of follicles:
- Mantle
zone (dark crescent)
- Light
zone
- Dark
zone
- Variation
in shape and size of follicles
- Frequent
mitotic figures
- B
cells:
- Concentrated
in follicles
- Scattered
cells in interfollicular areas
- Large
cell components of follicles:
- Centrocytes
- Centroblasts
- Follicular
dendritic cells
- Binucleate
- Prominent
red nucleoli
- Phagocytic macrophages (tingeable body macrophages)
- presence
of these cells DOESN’T equal benign
- they
reflect high cell turnover – so reactive follicles and higher grade
lymphomas will have them
Immunophenotype:
|
Marker:
|
Sensitivity:
|
Specificity:
|
|
CD10
(follicles)
|
|
|
|
Bcl-6
(follicles)
|
|
|
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Bcl-2
(extra-follicular)
|
|
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Molecular features:
Other features:
References: