Fetal Thrombotic
Vasculopathy
Epidemiology:
Common sites:
Gross features:
- well-circumscribed,
pale areas
- same
spongy consistency as surrounding tissue
Histologic
features:
- uniformly
avascular villi (3 or
more foci of 2 or more villi):
- involves
distal villi
- avascular villi
- sharp
demarcation from adjacent normal villi
- villi are normally spaced
- increased
bland stromal hyaline fibrosis
- villous
stromal-vascular karyorrhexis
(hemorrhagic endovasculitis) (3 or more foci of
2 or more villi):
- involves
distal villi
- karyorrhexis of fetal cells –
endothelium, stromal cells, blood cell
elements
- hypovascular villi
- degenerating
capillaries
- fragmented
red cells
- villitis of unknown etiology
(VUE) with obliterative fetal vasculopathy:
- VUE
extends to stem villi
- Stem villus vasculitis
- Thrombus
in a large vessel:
- 2 of
3 of:
- fibrin
strands
- glassy
texture
- endothelial
adherence
Immunophenotype:
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Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
References: