Prostatic Intraepithelial Neoplasm (PIN)

Common sites:

Gross features:

Histologic features:

• crowding and stratification of epithelial nuclei
• loss of polarity
• presence of basal cell layer
• prominent nucleoli (use 20X objective)

Immunophenotype:

Marker:	Sensitivity:	Specificity:
HMWK (basal layer)
34BE12 (basal layer)

Molecular features:

Other features: