Antiandrogen Therapy Effects on Adenocarcinoma

 

Epidemiology:

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Common sites:

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Gross features:

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Histologic features:

    • 3 different patterns:
      • atrophic prostate cancer:
      • histiocyte-like change:
        • pyknotic nuclei
        • abundant xanthomatous (foamy) cytoplasm
      • lymphocyte-like change:
    • fibrotic background
    • grade is artifactually higher
    • change in non-neoplastic tissue:
      • atrophy
      • basal cell hyperplasia
      • stromal fibrosis

 

Immunophenotype:

Marker:

Sensitivity:

Specificity:

 PSA

 

 

Pan-cytokeratin

 

 

 

Molecular features:

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Other features:

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References:

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