Nonspecific Granulomatous Prostatitis

Epidemiology:

Common sites:

Gross features:

Histologic features:

• looks different from infectious granulomatous inflammation of the prostate (usually)
• lobular, dense infiltrate of lymphocytes, plasma cells, and histiocytes
• many foamy macs
• some multinucleated macs
• neutrophils and eosinophils present in smaller numbers
• may have central necrosis (but neutrophils rather than caseation)
• obscuring and effacing ductal and acinar elements
• earliest lesion:
• dilated ducts and acini filled with neutrophils, debris, and desquamated epithelial cells
• rupture results in localized granulomatous and chronic inflammatory reaction

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

Other features:

• non-infectious
• thought to be local foreign body reaction to ruptured prostatic secretions and contents
• resolves spontaneously
• may cause obstructive symptoms or severe UTI
• nodularity or induration on rectal
• PSA levels rise
• Carcinoma often clinically suspected

References: