Allergic Bronchopulmonary Aspergillosis
(ABPA)
Epidemiology:
Common sites:
Gross features:
- peripherally-predominant
patchy infiltrate similar to CEP
- major bronchi may
show thick tenacious plugs of mucous
- bronchiectasis with chronicity
Histologic features:
- similar to CEP
- sloughing of
bronchial epithelial cells
- degenerating
cellular debris within bronchial lumen
- fungal hyphae in mucous rarely
- changes of chronic
asthmatic bronchitis may be seen
- thickenened epithelial basement membrane
- mucous gland
hyperplasia
- eosinophilic infiltration
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- caused by
hypersensitivity to noninvasive Aspergillus (or other fungi) occupying the lumen of
the bronchi within mucous or mucous plugs
- asthma commonly on
history
- blood eosinophilia common
- wheeze, cough,
sometimes hemoptysis
- radiographic
features of CEP
References: