XXXXXXXXXXXX

Epidemiology:

Common sites:

Gross features:

• bilateral patchy infiltrates
• peripheral > hilar

Histologic features:

• patchy
• pneumonic consolidation
• intraalveolar and terminal bronchiolar pattern of involvement
• exudate with many eos, lymphocytes, plasma cels, macrophages, and proteinaceous exudates and edema fluid
• distal bronchi and bronchiles may be distended by a thick mucous
• may contain cellular debris or intact PMNs, eosinophils, and sometimes Charcot-Leyden crystals
• interstitium widened by eosinophils, plasma cells, and lymphocytes
• bronchiolitis obliterans commonly
• poorly formed epithelioid granulomas occasionally
• within alveolar exudates, around blood vessels, or within the interstitium
• blood vessels may be infiltrated by inflammatory cells giving the impression of vasculitis
• no vascular necrosis however
• may have numerous intraalveolar macrophages around patchy foci of CEP

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

Other features:

• many have history of asthma
• reaction to drugs or fungi
• most often Aspergillus
• prolonged febrile illness
• cough
• weight loss
• generalized disability
• flood eosinophilia commonly

References:

• Sternberg 2004