Large CellNeuroendocrine Carcinoma (LCNEC)
Epidemiology and Etiology:
Common sites:
Gross features:
Histologic features:
- mitoses > 10 per
10HPF (distinguish from atypical carcinoid)
- necrosis may be
extensive
- architectural
patterns:
- organoid nesting
- trabecular pattern
- rosette-like
pattern
- palisading pattern
- non-small cell
cytologic features:
- low N/C ratio
- polygonal shape
- large size
- coarse or vesicular
nuclear chromatin
- frequent nucleoli
- no nuclear molding
- at least one
neuroendocrine marker positive on immunohistochemistry or neuroendocrine
granules by EM
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- Poor prognosis
(similar to small cell carcinoma)
References: