Nonspecific Interstitial Pneumonia (NSIP)
Epidemiology:
- 45-55y typically
- cellular pattern younger than fibrosing pattern
Common sites:
Gross features:
Histologic features:
- cellular pattern:
- mild to moderate chronic interstitial
inflammation
- lymphocytes and a few plasma cells
- uniform or patchy distribution
- type ii pneumocyte
hyperplasia
- fibrosing
pattern:
- diffuse or patchy interstitial fibrosis WITHOUT
the temporal heterogeneity characteristic of UIP
- absent fibroblastic foci
- mild to moderate chronic inflammation
- lymphoid aggregates maybe
- lung architecture preserved
Immunophenotype:
Marker:
|
Sensitivity:
|
Specificity:
|
|
|
|
Molecular features:
Other features:
- diffuse interstitial lung disease of unknown
etiology whose lung biopsies fail to show diagnostic features of any of
the other characterized interstitial diseases
- much better prognosis than UIP
- cellular pattern better prognosis
References: