Giant Cell Carcinoma (Lung)
Epidemiology and Etiology:
Common sites:
Gross features:
Histologic features:
- Almost entirely tumour giant cells (including
multinucleated cells)
- No differentiated carcinomatous elements
- Definitive diagnosis may only be made on
resection
- Giant tumour cells:
- Abundant, often eosinophilic, sometimes
granular cytoplasm
- Eosinophilic globules maybe
- Nuclei large, irregular, multilobated or
multiple, with coarse or vesicular chromatin and prominent nucleoli
- Neutrophil emperipolesis or infiltration maybe
- Bizarre shapes
- Discohesive growth
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Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- Poor prognosis, even in early stage
- Aggressive
- Distant mets commonly, including unusual
locations
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References:
- Travis et al. (eds.) WHO Classification of Tumours of the
Lung, Pleura, Thymus and Heart, 4th ed. (2015)
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