Idiopathic
Pulmonary Hemosiderosis
Epidemiology:
Common sites:
Gross features:
- moderately heavy
lungs
- red-brown to red
areas of consolidation
Histologic features:
- similar appearance
to Goodpasture syndrome
- hemorrhage into
alveolar spaces
- hemosiderosis within alveolar septa and in
intra-alveolar macrophages
- hyperplasia of
type II pneumocytes in some
- interstitial
fibrosis in some
- no vasculitis
- no inflammatory
infiltration
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- diagnosis of
exclusion
- clinical:
- insidious onset
- productive
cough, hemoptysis, anemia, weight loss
- diffuse
pulmonary infiltrates
- not associated
with renal disease
- unknown etiology;
possibly autoimmune
References: