Diffuse
Malignant Mesothelioma
(Malignant
Mesothelioma)
(Mesothelioma)
Epidemiology and
Etiology:
Common sites:
Gross features:
Histologic features:
Immunophenotype:
Marker: |
Sensitivity: |
Specificity: |
Calretinin |
(usually neg in
sarcomatoid mesothelioma) |
|
WT-1 |
(usually neg in
sarcomatoid) |
|
CK 5/6 |
(usually neg in
sarcomatoid) |
|
Thrombomodulin |
|
|
|
|
|
pankeratin (perinuclear accentuation) |
Great Usually
positive even in sarcomatoid mesothelioma (patchy or diffuse) |
Positive in
organizing pleuritis Usually
negative in sarcomas |
CK7 |
|
|
CK20 (neg) |
|
|
Mesothelin |
|
|
Thrombomodulin |
|
|
|
|
(Should be
positive in adenocarcinoma) |
CD15 (neg) |
|
(Should
be positive in adenocarcinoma) |
Ber EP4 (neg) |
|
(Should
be positive in adenocarcinoma) |
B72.3 (neg) |
|
(Should
be positive in adenocarcinoma) |
MOC 31 (neg) |
|
(Should
be positive in adenocarcinoma) |
TTF-1 (neg) |
|
(positive
in 70% of lung adenocarcinoma) |
PASD (neg) |
||
Mucicarmine or
alcian blue (pos) With previous
digestion by hyaluronidase (neg) |
|
|
Sarcomatoid
mesothelioma: |
|
|
Vimentin |
Maybe |
|
Actin |
Maybe |
|
Desmin |
Maybe |
|
S-100 |
Maybe |
|
Molecular features:
Other features:
References: