Bacterial
Pneumonia
Epidemiology and Etiology:
- Community-Acquired
Pneumonia:
- Streptococcus pneumoniae
- Haemophilus
influenzae
- Maraxella catarrhalis
- Staphylococcus
aureus
- Legionella
pneumophila
- Enterobacteriaceae
(Klebsiella pneumoniae) and Pseudomonas spp.
- Community-Acquired
Atypical Pneumonia
- Mycoplasma
pneumoniae
- Chlamydia spp. (C.
pneumoniae, C. psittaci, C. trachomatis)
- Coxiella burnetti
(Q fever)
- Viruses:
- RSV (children)
- parainfluenza
virus (children)
- influenza A and B
(adults)
- adenovirus
(military)
- SARS virus
- Nosocomial
pneumonia:
- Gram-negative rods
– Enterobacteriaceae (Klebsiella spp, Serratia marcescens, Escherichia
coli), Pseudomonas spp.
- Staphylococcus
aureus (usually penicillin-resistant)
- Aspiration
pneumonia
- Admixture of:
- Anaerobic oral
flora:
- Bacteroides
- Prevotella
- Fusobacterium
- Peptostreptococcus
- Aerobic bacteria
- Streptococcus
pneumoniae
- Staphylococcus
aureus
- Haemophilus
influenzae
- Pseudomonas
aeruginosa
- Chronic pneumonia
- Nocardia
- Actinomyces
- Granulomatous:
- Mycobacterium
tuberculosis
- atypical
mycobacteria
- Histoplasma
capsulatum
- Coccidioides
immitis
- Blastomyces
dermatitidis
- Necrotizing
pneumonia and Lung abscess
- Anaerobic bacteria
(extremely common), with or without mixed aerobic infection
- Staphylococcus
aureus
- Klebsiella
pneumoniae
- Streptococcus
pyogenes
- Type 3 pneumococcus
- Pneumonia in the
Immunocompromised:
- CMV
- Pneumocystis
carinii
- Mycobacterium avium-intracellulare
- Invasive
aspergillosis
- Invasive
candidiasis
- “usual” bacterial,
viral, and fungal organisms
Common sites:
Gross features:
- 2 patterns
(overlap):
- lobular
bronchopneumonia
- patchy
consolidation of the lung
- usually
multilobar, bilateral, basal > apical
- slightly elevated
lesions
- dry
- granular
- gray-red
to yellow
- poorly
delimited margins
- lobar pneumonia:
- consolidation of
a large portion of a lobe or entire lobe
- 4 stages
classically (natural coarse):
- congestion
- red
hepatization
- red
- firm
- airless
- liver-like
consistency
- grey
hepatization
- grayish
brown
- dry
appearance to cut surface
- resolution
- abscess in some
(type 3 pneumococci, Klebsiella
Histologic features:
- lobar pneumonia:
- four stages
classically (natural coarse):
- congestion
- vascular
engorgement
- intra-alveolar
fluid with few neutrophils
- numerous
bacteria
- red
hepatization
- massive
confluent exudation
- red
cells, neutrophils, and fibrin filling alveolar spaces
- gray
hepatization
- disintegration
of red cells
- persistent
fibrinopurulent exudate
- resolution
- exudate
is digested to form a granular, semifluid debris
- or
organization with fibroblasts
- bronchopulmonary
- suppurative,
neutrophil-rich exudate filling bronchi, bronchioles, and adjacent
alveolar spaces
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
References: