Radiation Effects

Epidemiology and Etiology:

Common sites:

Gross features:

Histologic features:

• acute:
• edema
• endothelila and epithelial cell death
• chronic:
• interstitial fibrosis
• intra-alveolar fibrosis
• blood vessel changes

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

• characteristic mutation in miners:
• GàT at codon 249 of p53 gene

Other features:

• induction of cancer
• miners are exposed to radon 222

References:

• Robbins 2005