Spindle Cell Carcinoma (Lung)
Epidemiology and Etiology:
Common sites:
Gross features:
Histologic features:
- Almost pure population of epithelial spindle
cells
- No differentiated carcinomatous elements
- Definitive diagnosis may only be made on
resection
- Fascicular or storiform
patterns
- Nuclei hyperchromatic with nucleoli and granular
chromatin often
- Inflammation common
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- Poor prognosis, even in early stage
- Aggressive
- Distant mets
commonly, including unusual locations
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References:
- Travis et al. (eds.) WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart, 4th
ed. (2015)
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