Basal Cell Adenoma / AdenoCarcinoma

 

Epidemiology:

    • elderly

 

Common sites:

    •  

 

Gross features:

    •  

 

Histologic features:

    • uniform basal cells
    • peripheral-cell palisading
    • solid trabecular structures
      • tubular pattern may be seen
    • clear separation from stroma by a well-defined basal membrane
      • may be a hyaline type resembling skin appendage tumour
    • infiltrative growth pattern distinguishes adenoma from adenocarcinoma
      • adjacent salivary gland
      • perineural invasion
      • intravascular invasion

 

Immunophenotype:

Marker:

Sensitivity:

Specificity:

 CEA

 

 

EMA

 

 

Cytokeratin

 

 

S100 (focal)

 

 

PAS (basement membrane material)

 

 

 

Molecular features:

    •  

 

Other features:

    •