Polymorphous Low-Grade Adenocarcinoma (PLGA)

Epidemiology and Etiology:

· 40s to 60s peak

Common sites:

· Palate

· Minor salivary glands

· (rare in major salivary glands)

Gross features:

·

Histologic features:

· Bland epithelial cells and myoepithelial cells

· Solid, cystic, ductal / glandular, cribriform, papillary, and lobular patterns

· Background matrix can be hyalinized or myxoid

· Difficult to differentiate from pleomorphic adenoma sometimes

· Infiltration of surrounding gland

· Perineural spread predilection

· Necrosis absent usually

· Mitoses low usually

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

·

Other features:

·

References:

· Silverberg SG, DeLellis RA, Frable WJ, LiVolsi VA, Wick MR. Silverberg's Principles and Practice of Surgical Pathology and Cytopathology: 2-Volume Set. 4th ed. Churchill Livingstone; 2005.