Sjogren Syndrome
Common sites:
Gross features:
Histologic features:
- salivary glands:
- earliest:
- periductal and
perivascular lymphocytic infiltration
- then:
- extensive
lymphocytic infiltrate
- may
see lymphoid follicles in larger salivary glands
- hyperplasia of
ductal epithelium
- later:
- atrophy of acini
- fibrosis and
hyalinization
- still later:
- atrophy and
replacement of parenchyma with fat
- cornea:
- inflammation
- erosions and
ulcerations
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features: