Salivary Duct Carcinoma

Epidemiology:

• Middle-aged and elderly men

Common sites:

• parotid primarily

Gross features:

Histologic features:

• intraductal component similar to ductal carcinoma of the breast
• papillary, comedo-like, or cribriform patterns
• infiltrating component
• papillary or non-specific, undifferentiated pattern
• moderately abundant eosinophilic cytoplasm
• mitotic figures common

Immunophenotype:

Marker:	Sensitivity:	Specificity:
Cytokeratin
EMA
CEA
SMA (neg)

Molecular features:

Other features:

• aggressive