Small Cell Carcinoma (neuroendocrine Carcinoma)

Epidemiology:

Common sites:

• minor salivary glands
• larynx, paranasal sinuses, nasal and oral cavities, pharynx

Gross features:

Histologic features:

• sheets, strands, nests
• rosette formation may be present
• oval cells
• hyperchromatic, coarsely granular nuclei
• scanty cytoplasm
• high mitotic rate

Immunophenotype:

Marker:	Sensitivity:	Specificity:
Synaptophysin
Chromogranin
Neuron-specific enolase

Molecular features:

Other features:

• if no staining for neuroendocrine markers, should classify as small cell undifferentiated salivary duct carcinoma