Cutaneous Crohn Disease
Epidemiology and Etiology:
Common sites:
- oral
- perianal
- peristomal
- skin distant to
mouth or anus
- flexural areas
- lower
extremities
- penis
- vulva
Gross features:
- oral:
- cobblestoning
- facial/lip
swelling
- linear ulcers
- perianal:
- fistulas
- sinus tracts
- ulcers
- skin (distant from
mouth or anus):
- disseminated
nodules or plaques
- ulcerated often
Histologic features:
- noncaseating granulomatous
inflammation
- pallisaded granulomas
may be present
- granulomatous vasculitis
may be present
- lymphocytes,
plasma cells
- often extends deep
into subcutaneous tissue
- septolobular panniculitis
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- bowel disease may
be quiescent with active skin disease (rarely)
References: