Pyoderma Gangrenosum
Epidemiology:
Common sites:
Gross features:
- stages of
development:
- erythematous paule
- pustule
- ulcer (deep,
painful) with undermined violaceous borders
Histologic features:
- similar to acute
febrile neutrophilic dermatosis,
but more extensive
- dense dermal neutrophilic infiltrate
- dermal necrosis
- ulceration in
later stage
- leukocytoclastic vasculitis
may be present
- some lesions begin
as neutrophilic folliculitis
Immunophenotype:
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Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- frequently
associated with UC, myeloma, leukemia, and
hepatitis
References: