Squamous Cell Carcinoma

Epidemiology and Etiology:

Common sites:

Gross features:

Histologic features:

Immunophenotype:

Marker:	Sensitivity:	Specificity:
(spindle cell SCC)
CK 5/6
P63

Molecular features:

Other features:

• Adverse prognostic factors:
• Histologic subtype:
• Adenoid
• Basaloid
• Small cell
• Spindle cell
• Post-traumatic clinicopathological subtype
• Extensive perineural invasion
• Extensive lymphatic invasion
• Extensive vascular invasion
• Invasion into subcutis
• Surgical margin positivity

References: