Acute Febrile Neutrophilic Dermatosis (Sweet Syndrome)

Epidemiology:

Common sites:

• upper extremities and face

Gross features:

• erythematous papules and plaques with superimposed pustules

Histologic features:

• dense diffuse neutrophilic infiltrate in upper and mid reticular dermis
• leukocytoclasia is present
• other features of vasculitis are not present
• edema in upper dermis
• subepidermal bullae may be present

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

Other features:

• Fever and leukocytosis may accompany the rash
• Associated with acute myelogenous leukemia (AML)

References: