Cutaneous Adenoid Cystic Carcinoma

Epidemiology and Etiology:

Common sites:

Gross features:

Histologic features:

• cribriform or “punched out” configuration
• rare attachment to epidermis or hair follicles
• perineural invasion is common
• mitotic activity is rare
• peripheral pallisading is uncommon

Immunophenotype:

Marker:	Sensitivity:	Specificity:
CEA (absent in BCC)	Variable
CD117 (absent in BCC)
PAS-positive material (absent in BCC)

Molecular features:

•  t(6;9)(q22-23;p23-24)
• MYB-NFIB fusion gene

Other features:

References:

• Barnhill 2004