Fixed Drug
Eruption
Epidemiology:
Common sites:
Gross features:
- repeated
administration of certain drugs results in recurrence in the same
location
- reddish brown
patch
- bullae maybe
Histologic features:
- scattered individual and grouped dyskeratotic (necrotic) keratinocytes
- brightly eosinophilic cytoplasm
- pyknotic nuclei
- found at all
levels of epidermis
- focal vacuolar
interface change
- melanophages in the papillary and upper reticular
dermis
- perivascular lymphocytic
infiltrates in reticular dermis
- interstitial eosinophils
- bulllae, if present, are subepidermal
- occurs in areas
of severe vacuolar interface change
Immunophenotype:
|
Marker:
|
Sensitivity:
|
Specificity:
|
|
|
|
|
Molecular features:
Other features:
- drugs:
- tetracycline
- barbiturates
- phenolphthalein
References: