Microcystic Adnexal Carcinoma
Epidemiology and Etiology:
Common sites:
Gross features:
- plaque or nodule
- flesh-coloured to yellow
- slowly growing
Histologic features:
- dermal-centred tumour
- extensive
infiltration of deep dermis and subcutaneous tissues
- perineural invasion often
- keratocysts, trabeculae,
and ductules
- keratocysts predominate superficially
- trabeculae and ductules
predominate at deeper aspect
- all 3 in middle
of tumour
- dense fibrous stroma investing the epithelial units
- mitoses rare
- necrosis uncommon
Immunophenotype:
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Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- locally aggressive
- does not tend to
metastasize
References:
- Barnhill 2004
- Essentials of AP 2006