Radiation Effects

Epidemiology and Etiology:

Common sites:

Gross features:

• acute:
• erythema

Histologic features:

• delayed (radiation dermatitis):
• atrophy of epidermis
• hyperkeratosis
• hyperpigmentation
• hypopigmentation
• fibrosis of dermis
• dense bands of collagen surrounding dilated, “weakened” subcutaneous vessels
• may see:
• ulceration

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

Other features:

• may induce cancer:
• especially basal cell and squamous cell carcinomas

References:

• Robbins 2005