Rheumatoid
Nodule
Epidemiology and Etiology:
- 20% of adults with
rheumatoid arthritis
- likely
pathogenesis:
- immune
complex-mediated vasculitis
- ischemia in
subcutaneous tissues
- palisaded granulomatous
inflammatory reaction
Common sites:
- subcutaneous (over
joints)
- elbows
classically
- knuckles
- achiles tendon
- weight-bearing
parts of foot
- lung
- heart
- GI tract
Gross features:
Histologic features:
- Involving subcutaneous
tissue and maybe lower dermis
- Palisaded granulomatous
dermatitis
- Large area of
homogenous , eosinophilic, fibrinoid
necrosis
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
References: