Low-Grade
Fibromyxoid Sarcoma
Epidemiology:
Common sites:
Gross features:
Histologic features:
- deceptively
bland; similar appearance to fibromatosis and nerve sheath tumour
- slight
whirling, partially storiform appearance
- may be
extremely hypocellular
- small,
thin, spindly cells
- bent
and wavy nuclei occasionally
- mitotic activity can be
extremely low
- giant
hyalinizing rosettes with collagenized may be present
- rare
S100 positive cells may be present in rosettes
Immunophenotype:
Marker:
|
Sensitivity:
|
Specificity:
|
S100
(neg)
|
|
|
Molecular features:
Other features:
- May
metastasize (<10%), often years after removal of primary
References: