Skeletal Muscle Reactions

Epidemiology and Etiology:

Common sites:

Gross features:

Histologic features:

· Segmental necrosis:

o Destruction of a portion of the length of a myocyte

o Myophagocytosis – macrophages infiltrating the region

o Collagen deposition

o Fatty infiltration

· Vacuolation

· Alterations in structural proteins or organelles

· Accumulation of intracytoplasmic deposits

· Regeneration

o Muscle fibre with large internalized nuclei with prominent nucleoli

o Basophilic cytoplasm (RNA)

· Hypertrophy

o Muscle fibre splitting

§ Cell membrane splitting a fibre in two, often with adjacent nuclei

o

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

Other features:

References: