Spindle cell hemangioma

(Formerly Spindle cell hemangioendothelioma)

Epidemiology and Etiology:

· Children and young adults usually

· May arise from local vascular malformations

Common sites:

· Dermal and subcutaneous

· Distal extremities

· Solitary usually

Gross features:

·

Histologic features:

· Biphasic pattern

· Dilated cavernous vascular spaces

· Solid spindle cell areas

· Solid spindle cell areas:

· Slit-like vascular channels resembling those of KS

· Contain plumper endothelial cells with cytoplasmic vacuoles simulating hemangioendothelioma

· Modest nuclear atypia

· Rare mitotic figures

· Intralesional thrombi maybe

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

·

Other features:

· Local recurrences common

· May actually represent metachronous growth of multicentric lesions

References:

· Silverberg SG, DeLellis RA, Frable WJ, LiVolsi VA, Wick MR. Silverberg's Principles and Practice of Surgical Pathology and Cytopathology: 2-Volume Set. 4th ed. Churchill Livingstone; 2005:2656.