Intratubular Germ Cell Neoplasm (ITCGN)

Epidemiology:

• Risk factors:
• Cryptorchidism
• Androgen insensitivity syndrome
• Gonadal dysgenesis syndrome
• Family history

Common sites:

Gross features:

Histologic features:

• thickened basement membrane often
• atypical germ cells within seminiferous tubules
• abundant vacuolated cytoplasm (glycogen-rich)
• large, irregular nuclei
• hyperchromatic
• prominent irregular nucleoli
• basally located
• spermatogenesis absent usually
• mitoses often

Immunophenotype:

Marker:	Sensitivity:	Specificity:
c-kit		Normal seminiferous tubules are negative
PLAP	83-99%	Normal seminiferous tubules are negative
Oct ¾		Normal seminiferous tubules are negative
PAS
Cytokeratin (neg)
CD30 (neg)
AFP (neg)
Beta-HCG (neg)

Molecular features:

Other features:

• progresses in 50% over 5y