Teratoma
Gross features:
- large (5-10cm)
- heterogenous
appearance
- solid,
cartilagenous, cystic areas
- hemorrhage &
necrosis if mixed with embryonal or choriocarcinoma
Histologic features:
- heterogeneous
collection of differentiated cells and organoid structures, such as:
- clusters of squamous epithelium
- brain substance
- intestinal wall
- neural tissue
- muscle bundles
- islands of
cartilage
- thyroid gland
structures
- bronchial or
bronchiolar epithelium
- embedded in a
fibrous or myxoid stroma
- immature areas:
- organized
tissues and stroma composed of small blue
cells
- immature mesenchyme – very cellular, spindle cells
- rarely, focus of
non-germ cell malignancy
Immunophenotype:
|
Marker:
|
Sensitivity:
|
Specificity:
|
|
|
|
|
Molecular features:
Other features:
- behaviour depends on age in males:
- benign in
children
- malignant post-puberty